Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heart Failure I: Introduction01:27

Heart Failure I: Introduction

1.4K
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
1.4K
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

941
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
941
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

4.8K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
4.8K
Heart Failure VII: Nursing Interventions01:30

Heart Failure VII: Nursing Interventions

763
The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...
763
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

3.5K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
3.5K
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

1.5K
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Engaging Peer Mentors for Opportunity, Well-Being, and Equity Realization-A Leadership Intervention for Women in Academic Medicine.

Journal of women's health (2002)·2025
Same author

Adrenergic Polymorphisms and Survival in African Americans With Heart Failure: Results From A-HeFT.

Journal of cardiac failure·2019
Same author

Association of Variants in BAG3 With Cardiomyopathy Outcomes in African American Individuals.

JAMA cardiology·2018
Same author

A common variant alters SCN5A-miR-24 interaction and associates with heart failure mortality.

The Journal of clinical investigation·2018
Same author

Heart Failure With Recovered Ejection Fraction in African Americans: Results From the African-American Heart Failure Trial.

Journal of cardiac failure·2017
Same author

Mentored Training to Increase Diversity among Faculty in the Biomedical Sciences: The NHLBI Summer Institute Programs to Increase Diversity (SIPID) and the Programs to Increase Diversity among Individuals Engaged in Health-related Research (PRIDE).

Ethnicity & disease·2017

Related Experiment Video

Updated: Apr 18, 2026

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach
07:49

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach

Published on: July 21, 2023

2.1K

Heart failure in women.

Anne L Taylor1

  • 1Columbia University Medical Center, 630 W. 168th Street, PH 1-132, New York, NY, 10032, USA, alt2127@cumc.columbia.edu.

Current Heart Failure Reports
|January 31, 2015
PubMed
Summary

Heart failure (HF) affects many women, often due to hypertension, leading to HF with preserved ejection fraction (HFpEF). Despite sex-based differences in HF outcomes and disease mechanisms, women remain underrepresented in clinical trials, limiting sex-specific treatment evidence.

Area of Science:

  • Cardiology
  • Sex-Based Medicine
  • Clinical Trials

Background:

  • Heart failure (HF) incidence is rising globally, with women comprising approximately 50% of patients.
  • Significant sex-based disparities exist in HF etiology, clinical presentation, prognosis, and treatment response.
  • Hypertension is a more prevalent cause of HF in women than coronary artery disease, with HF with preserved left ventricular ejection fraction (HFpEF) being more common.

Purpose of the Study:

  • To highlight the significant sex-based differences in heart failure (HF) across various aspects of the disease.
  • To underscore the underrepresentation of women in HF clinical trials and its implications for evidence-based treatment.

Main Methods:

  • Comparative analysis of heart failure (HF) in women versus men, examining disease etiology, expression, outcomes, and response to therapy.

More Related Videos

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

7.2K
Author Spotlight: Unveiling Prognostic Indicators in Heart Failure - The Role of Phase Angle and Bioelectrical Impedance Analysis
04:05

Author Spotlight: Unveiling Prognostic Indicators in Heart Failure - The Role of Phase Angle and Bioelectrical Impedance Analysis

Published on: June 30, 2023

3.0K

Related Experiment Videos

Last Updated: Apr 18, 2026

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach
07:49

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach

Published on: July 21, 2023

2.1K
Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

7.2K
Author Spotlight: Unveiling Prognostic Indicators in Heart Failure - The Role of Phase Angle and Bioelectrical Impedance Analysis
04:05

Author Spotlight: Unveiling Prognostic Indicators in Heart Failure - The Role of Phase Angle and Bioelectrical Impedance Analysis

Published on: June 30, 2023

3.0K
  • Review of existing literature and clinical trial data regarding sex differences in HF and trial participation.

    • Main Results:

    • Women with HF exhibit distinct etiological profiles, predominantly hypertension-driven, and a higher prevalence of HFpEF.
    • Despite better survival rates and lower sudden cardiac death incidence, women report poorer quality of life compared to men with similar left ventricular dysfunction.
    • Animal studies confirm sex-specific differences in myocardial remodeling and function under stress.

    Conclusions:

    • Sex-based differences in heart failure are substantial, impacting disease mechanisms, clinical outcomes, and quality of life.
    • The persistent underrepresentation of women in clinical trials (around 20%) and the lack of sex-specific subgroup analyses hinder the development of robust, evidence-based treatment guidelines for female HF patients.