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Related Concept Videos

Tracheostomy: Procedure and Tubes01:28

Tracheostomy: Procedure and Tubes

5.7K
A tracheostomy is a surgical procedure that creates an artificial opening into the trachea, typically at the second or third cartilaginous ring level. This opening allows the insertion of a tracheostomy tube, which can replace an endotracheal tube, provide mechanical ventilation, bypass an upper airway obstruction, or remove accumulated tracheobronchial secretions.
Tracheostomy tubes can be made of semiflexible plastic (polyurethane or silicone), rigid plastic, or metal, and they come in...
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Oxygen Delivering System III: Tracheostomy and T-piece01:23

Oxygen Delivering System III: Tracheostomy and T-piece

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Oxygen delivery is critical in clinical care, especially for patients with respiratory disorders or those undergoing surgical procedures. Various systems, such as tracheostomy and the T-piece, deliver oxygen to the lungs, ensuring adequate arterial oxygenation.
Tracheostomy
A tracheostomy is a surgically created opening (stoma) in the anterior part of the trachea. It is used to establish a patient airway, bypass an upper airway obstruction, simplify the removal of secretions, permit long-term...
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Tracheostomy Care II: Procedure01:25

Tracheostomy Care II: Procedure

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Tracheostomy care is an essential nursing skill that involves cleaning and maintaining a tracheostomy tube to prevent infection and other complications. Here's a step-by-step guide explaining each procedure with its rationale. Note that disposable gloves are to be worn at all times and changed as often as needed to maintain a sterile work environment, and to protect both patient and healthcare worker.
Step 1: Perform hand hygiene, and put on personal protective equipment: gown, gloves, mask...
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Trachea01:22

Trachea

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The trachea, commonly known as the windpipe, is a vital part of the human respiratory system. It serves as a passageway for air to travel between the larynx and the bronchi, allowing oxygen to reach the lungs. Let's explore its anatomical features, dimensions, layers of the tracheal wall, associated muscles, and the functions of its parts.
Anatomical Features:
Location: About half of the trachea is situated in the neck, anterior to the esophagus, and extends from the larynx (at the level of...
6.5K
Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen01:16

Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen

3.6K
Oxygen therapy is a pivotal aspect of medical care, particularly for patients with respiratory ailments. Two prominent oxygen-delivering systems include the Venturi mask and the transtracheal oxygen catheter.
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
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Tracheostomy Decannulation01:21

Tracheostomy Decannulation

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Tracheostomy decannulation is a significant milestone in the liberation of mechanically ventilated patients. Despite its importance, there is no universally accepted protocol for this procedure. This demands an evidence-based, individualized approach.
Description of the Procedure
Decannulation refers to the permanent removal of the tracheostomy tube, signaling the resolution of the condition that initially necessitated the tracheostomy. The process requires a well-coordinated interplay between...
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Related Experiment Video

Updated: Apr 18, 2026

Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model
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Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model

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Patient-specific carbon nanocomposite tracheal prosthesis.

Matthew Chua1, Chee-Kong Chui, Constance Teo

  • 11 Department of Mechanical Engineering, National University of Singapore, Singapore - Singapore.

The International Journal of Artificial Organs
|January 31, 2015
PubMed
Summary

A new patient-specific artificial trachea made from carbon nanotubes and poly-di-methyl-siloxane (CNT-PDMS) shows promise for airway reconstruction. This biocompatible graft supports cell growth and demonstrates successful in vivo regeneration in animal models.

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Low-Dose Gamma Radiation Sterilization for Decellularized Tracheal Grafts
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Area of Science:

  • Biomaterials Engineering
  • Regenerative Medicine
  • Surgical Innovation

Background:

  • Tracheal resection for carcinoma or stenosis often requires grafts due to significant length loss.
  • Current tracheal prostheses face high failure rates due to mechanical property mismatch and poor epithelialization.
  • A need exists for patient-specific tracheal implants that closely match anatomical and functional requirements.

Purpose of the Study:

  • To develop and evaluate a patient-specific artificial trachea using a carbon nanotube and poly-di-methyl-siloxane (CNT-PDMS) composite.
  • To assess the mechanical properties and biocompatibility of the novel tracheal prosthesis.
  • To investigate the potential of the CNT-PDMS graft for airway reconstruction in severe tracheal conditions.

Main Methods:

  • Computational simulations and finite element analysis were employed to model patient-specific tracheal implants.
  • In vitro studies were conducted to evaluate the biocompatibility and cellular response of the CNT-PDMS material.
  • In vivo studies using porcine models were performed to assess the safety and efficacy of the artificial trachea.

Main Results:

  • Finite element analysis confirmed that the patient-specific CNT-PDMS prosthesis exhibits stress distributions similar to the natural trachea.
  • In vitro testing demonstrated the material's biocompatibility and ability to support tracheal epithelial cell proliferation and differentiation.
  • In vivo studies in pigs showed no adverse effects, with complete tracheal epithelium regeneration within two weeks.

Conclusions:

  • The patient-specific CNT-PDMS graft presents a viable and promising solution for airway replacement in cases of severe tracheal carcinoma.
  • This novel biomaterial addresses limitations of current tracheal prostheses, including mechanical mismatch and slow tissue regeneration.
  • The study supports the potential of personalized implants in advancing reconstructive surgery for complex airway defects.