[Cognitive Function and Calcium. NMDA receptor activity dependent intracellular Ca increase in neurons]
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Updated: Apr 18, 2026

A High-throughput Calcium-flux Assay to Study NMDA-receptors with Sensitivity to Glycine/D-serine and Glutamate
Published on: July 10, 2018
1Department of Chronomedicine, Hokkaido University Graduate School of Medicine, Japan.
Abstract:
Many studies have suggested that NMDAR have critical roles in the mechanisms for learning and memory. They are also thought to be involved in neuronal dysfunctions and mental disorders. Since NMDARs have high permeability to Ca2+, most studies indicate that Ca influx through NMDAR ion channels are important to mediate various neuronal activities and intracellular signaling pathways. Our research have shown that intracellular Ca2+ increase during NMDAR dependent depolarization is a secondary process via voltage gated calcium channels.
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