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Association between three eNOS polymorphisms and intracranial aneurysms risk: a meta-analysis.
Chao Yang1, Zhen-Yu Qi, Chuan Shao
1From the Department of Neurosurgery (CY, ZQ, WX, ZW), The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu; and Department of Neurosurgery (CS), The Second Clinical Medical College of North Sichuan Medical College, Nanchong, Sichuan, China.
Medicine
|January 31, 2015
Summary
This meta-analysis found no overall link between eNOS gene variations and intracranial aneurysm (IA) risk. However, the T786C polymorphism showed an increased IA risk specifically in Asian populations.
Area of Science:
- Genetics
- Cardiovascular Science
- Neuroscience
Background:
- Endothelial nitric oxide synthase (eNOS) produces nitric oxide (NO), crucial for vascular function.
- Genetic variations (polymorphisms) in the eNOS gene are investigated for their role in intracranial aneurysm (IA) susceptibility.
- Previous research on eNOS polymorphisms and IA risk has yielded inconsistent findings.
Purpose of the Study:
- To conduct a meta-analysis to precisely evaluate the association between common eNOS gene polymorphisms (T786C, G894T, 27-bp-VNTR) and the risk of developing IA.
- To resolve inconsistencies in existing studies regarding the genetic contribution of eNOS to IA.
- To investigate potential ethnic differences in the association between eNOS polymorphisms and IA risk.
Main Methods:
- A systematic literature search was performed across major databases (PubMed, Embase, Web of Science, Wanfang) up to July 2014.
- Case-control studies investigating the association between eNOS polymorphisms (T786C, G894T, 27-bp-VNTR) and IA were included.
- Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using fixed or random-effects models for meta-analysis.
Main Results:
- The overall meta-analysis revealed no significant association between the studied eNOS polymorphisms and the overall risk of IA.
- Subgroup analysis by ethnicity indicated a significantly increased risk of IA associated with the T786C polymorphism among Asian individuals.
- No significant association was found for the T786C polymorphism in Caucasians, nor for the G894T and 27-bp-VNTR polymorphisms in any ethnic group.
Conclusions:
- The eNOS T786C polymorphism is associated with an elevated risk of intracranial aneurysm, particularly in Asian populations.
- The eNOS G894T and 27-bp-VNTR polymorphisms do not appear to significantly influence the susceptibility to intracranial aneurysms.
- Further research may be warranted to elucidate the specific mechanisms underlying the ethnic-specific association of eNOS T786C with IA risk.
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