Related Experiment Video
Updated: Apr 18, 2026

Formulation and Characterization of Bioactive Agent Containing Nanodisks
Published on: March 17, 2023
DQAsomes as the prototype of mitochondria-targeted pharmaceutical nanocarriers: preparation, characterization, and
1Department of Pharmaceutical Sciences, College of Pharmacy Glendale, Midwestern University, Glendale Hall 236-18, 19555 N 59th Avenue, Glendale, AZ, 85308, USA, vweiss@midwestern.edu.
Abstract:
DQAsomes (dequalinium-based liposome-like vesicles) are the prototype for all mitochondria-targeted vesicular pharmaceutical nanocarrier systems. First described in 1998, they have been successfully explored for the delivery of DNA and low-molecular weight molecules to mitochondria within living mammalian cells. Potential areas of application involve mitochondrial gene therapy, antioxidant therapy as well as apoptosis-based anticancer chemotherapy. Here, detailed protocols for the preparation, characterization, and application of DQAsomes are given.

