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Related Concept Videos

Micelles01:30

Micelles

282
Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...
282
Lipids as Anchors01:32

Lipids as Anchors

8.1K
In the plasma membrane, the lipids forming the bilayer can also act as an anchor to tether proteins to the membrane. The three main types of lipid anchors found in eukaryotes are – prenyl groups, fatty acyl groups, and glycosylphosphatidylinositol or GPI groups. Prenyl and fatty acyl groups act as anchors on the cytosolic surface of the membrane, whereas GPI anchors proteins on the extracellular side.
The carboxy-terminal of most of the prenylated proteins, such as Ras proteins, contains...
8.1K

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Related Experiment Video

Updated: Apr 18, 2026

Preparation, Purification, and Use of Fatty Acid-containing Liposomes
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Preparation, Purification, and Use of Fatty Acid-containing Liposomes

Published on: February 9, 2018

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Controlling lipid micelle stability using oligonucleotide headgroups.

Samantha E Wilner1, Samuel E Sparks, David Cowburn

  • 1Department of Biochemistry, Albert Einstein College of Medicine , Bronx, New York 10461, United States.

Journal of the American Chemical Society
|January 31, 2015
PubMed
Summary
This summary is machine-generated.

Engineered lipid-based micelles with oligonucleotide extensions demonstrate enhanced stability in serum. This innovation allows for controlled drug delivery and release, overcoming previous limitations of micelle instability in biological fluids.

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Area of Science:

  • Nanotechnology
  • Biochemistry
  • Materials Science

Background:

  • Lipid-based micelles are promising for drug delivery due to their small size and solubility enhancement capabilities.
  • Micelle instability in serum, caused by protein interactions, limits their therapeutic applications.
  • Current strategies struggle to maintain micelle integrity in biological environments.

Purpose of the Study:

  • To engineer lipid-based micelles with enhanced stability in serum.
  • To investigate the role of oligonucleotide extensions in micelle stabilization.
  • To demonstrate controlled cargo release through micelle destabilization.

Main Methods:

  • Lipid-based micelles were functionalized with short, quadruplex-forming oligonucleotide extensions.
  • Quadruplex formation on micelle surfaces was confirmed using proton nuclear magnetic resonance ((1)H NMR).
  • Micelle stability was assessed through incubation with serum proteins over time.
  • Cargo release was triggered by disrupting the oligonucleotide quadruplex structures using antisense oligonucleotides.

Main Results:

  • Oligonucleotide quadruplex formation on micelle surfaces conferred stability against serum protein-induced disassembly for over 24 hours.
  • The quadruplex structure slightly distorted micelle morphology.
  • Disruption of the quadruplex structure led to micelle destabilization and subsequent cargo release.
  • (1)H NMR confirmed the presence and integrity of the quadruplex structures.

Conclusions:

  • Engineered micelles with oligonucleotide headgroups offer a novel strategy for stabilizing lipid nanoparticles in serum.
  • Oligonucleotide interactions provide a mechanism for externally controlling micelle stability and drug release.
  • This approach represents a new paradigm for designing programmable nanoscale devices for therapeutic and diagnostic applications.