Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autophagy01:27

Autophagy

6.5K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
6.5K
Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

10.6K
Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
10.6K
Overview of the Vascular System01:20

Overview of the Vascular System

3.8K
The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
3.8K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

4.0K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
4.0K
Autophagic Cell Death01:18

Autophagic Cell Death

5.1K
Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
5.1K
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

646
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
646

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development and reliability testing of BRANT-MERQS-2A: A quality assessment tool for medication review type 2a reports.

International journal of clinical pharmacy·2026
Same author

The INSPIRE doctoral network in safety pharmacology - Looking back and ahead.

Journal of pharmacological and toxicological methods·2026
Same author

Identification of small-molecule autophagy activators via GFP-LC3 high-throughput screening and a cargo-based autophagy flux and processing assay.

European journal of pharmacology·2026
Same author

ERBB4 activation as a new therapy for atrial remodeling and fibrillation.

Heart rhythm·2026
Same author

Senescence as a Driver of Smooth Muscle Cell Plasticity and Atherosclerosis: Mechanisms and Therapeutic Opportunities.

Cells·2026
Same author

Vectorized ULK1/2 and VPS34 Inhibitors for Tissue-Selective Autophagy Inhibition in Oncology.

Journal of medicinal chemistry·2026

Related Experiment Video

Updated: Apr 18, 2026

Precision Ultrasound-guided Stem Cell Delivery for Vascular Repair in Aortic Diseases
04:59

Precision Ultrasound-guided Stem Cell Delivery for Vascular Repair in Aortic Diseases

Published on: June 20, 2025

989

Autophagy in vascular disease.

Guido R Y De Meyer1, Mandy O J Grootaert2, Cédéric F Michiels2

  • 1From the Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium. guido.demeyer@uantwerpen.be.

Circulation Research
|January 31, 2015
PubMed
Summary

Autophagy, a cellular repair process, is vital for vascular health and protects against atherosclerosis. Stimulating autophagy shows promise for treating vascular diseases like atherosclerosis and aneurysms.

Keywords:
atherosclerosisautophagyvascular diseases

More Related Videos

Assessment of Vascular Regeneration in the CNS Using the Mouse Retina
07:32

Assessment of Vascular Regeneration in the CNS Using the Mouse Retina

Published on: June 23, 2014

15.0K
Quantification of Vascular Parameters in Whole Mount Retinas of Mice with Non-Proliferative and Proliferative Retinopathies
12:28

Quantification of Vascular Parameters in Whole Mount Retinas of Mice with Non-Proliferative and Proliferative Retinopathies

Published on: March 12, 2022

4.5K

Related Experiment Videos

Last Updated: Apr 18, 2026

Precision Ultrasound-guided Stem Cell Delivery for Vascular Repair in Aortic Diseases
04:59

Precision Ultrasound-guided Stem Cell Delivery for Vascular Repair in Aortic Diseases

Published on: June 20, 2025

989
Assessment of Vascular Regeneration in the CNS Using the Mouse Retina
07:32

Assessment of Vascular Regeneration in the CNS Using the Mouse Retina

Published on: June 23, 2014

15.0K
Quantification of Vascular Parameters in Whole Mount Retinas of Mice with Non-Proliferative and Proliferative Retinopathies
12:28

Quantification of Vascular Parameters in Whole Mount Retinas of Mice with Non-Proliferative and Proliferative Retinopathies

Published on: March 12, 2022

4.5K

Area of Science:

  • Cellular Biology
  • Vascular Biology
  • Biochemistry

Background:

  • Autophagy is a fundamental cellular process for degrading damaged components.
  • Basal autophagy is crucial for maintaining vascular integrity and function.
  • Dysfunctional autophagy is implicated in various vascular pathologies, including atherosclerosis.

Purpose of the Study:

  • To review the role of autophagy in vascular health and disease.
  • To highlight the therapeutic potential of autophagy modulation in vascular disorders.
  • To discuss current and emerging pharmacological interventions for vascular diseases.

Main Methods:

  • Literature review of studies on autophagy in vascular biology.
  • Analysis of preclinical and clinical data on autophagy inducers.
  • Synthesis of evidence regarding autophagy's role in atherosclerosis, aneurysm, and aging.

Main Results:

  • Autophagy is atheroprotective in early stages but becomes impaired in advanced plaques.
  • Autophagy inducers like rapamycin (rapalogs) show efficacy in inhibiting atherosclerotic plaque progression.
  • Other agents like spermidine and combination therapies (statins, metformin) may also prevent vascular disease.

Conclusions:

  • Modulating autophagy presents a promising therapeutic strategy for vascular diseases.
  • Pharmacological stimulation of autophagy could offer novel treatments for atherosclerosis and other vascular conditions.
  • Further research is needed to explore autophagy's role in diverse vascular disorders.