The chemokine system in innate immunity
Caroline L Sokol1, Andrew D Luster1
1Center for Immunology & Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114.
Cold Spring Harbor Perspectives in Biology
|January 31, 2015
Summary
Chemokines guide immune cell movement for tissue repair and adaptive immunity. This review details how chemokines regulate innate immune cells during homeostasis and inflammation, linking innate and adaptive responses.
Area of Science:
- Immunology
- Cell Biology
Background:
- Chemokines are cytokines crucial for immune cell migration and tissue positioning.
- They regulate innate immune cell release from bone marrow and recruitment to inflammation sites.
Purpose of the Study:
- To review recent advances in understanding chemokine function in innate immune cell regulation.
- To highlight the role of chemokines in linking innate and adaptive immunity.
Main Methods:
- Literature review of recent research on chemokine function.
- Analysis of chemokine-mediated immune cell trafficking during homeostasis and inflammation.
Main Results:
- Chemokines control innate immune cell movement from bone marrow to tissues.
- They guide immune cells to injury sites and draining lymph nodes.
- Chemokine signaling is essential for initiating adaptive immune responses.
Conclusions:
- Chemokines are vital for innate immune cell positioning and function.
- Chemokine-mediated trafficking links innate immunity to adaptive immune activation.
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