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Emerging therapy for adrenocortical carcinoma

Rachel D Aufforth1, Naris Nilubol1

  • 1Endocrine Oncology Branch, National Cancer Institute, NIH, Bethesda, MD, USA.

International Journal of Endocrine Oncology
|January 31, 2015
PubMed

Insights

Adrenocortical carcinoma (ACC) is a rare, aggressive cancer. Current treatments involve surgery or mitotane, but new molecular targets offer future treatment possibilities.

Area of Science:

  • Oncology
  • Endocrinology
  • Cancer Genetics

Background:

  • Adrenocortical carcinoma (ACC) is a rare and aggressive endocrine tumor.
  • Current treatments include surgical resection and systemic therapy with mitotane.
  • Outcomes for advanced ACC remain poor.

Purpose of the Study:

  • To review current treatment options for adrenocortical carcinoma.
  • To discuss emerging molecular targets for ACC treatment.

Main Methods:

  • Literature review of current ACC treatments.
  • Analysis of recent molecular profiling studies in ACC.

Main Results:

  • Complete surgical resection is standard for localized disease.
  • Mitotane is the primary systemic therapy for advanced ACC.
  • Molecular profiling has identified several new potential therapeutic targets.

Conclusions:

  • Despite advances, ACC remains challenging to treat.
  • Targeted therapies based on molecular profiling hold promise for future ACC treatment strategies.
Keywords:
adrenocortical carcinomagenomicsmolecular profilingsystemic treatment

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