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Updated: Apr 18, 2026

Methyl-binding DNA capture Sequencing for Patient Tissues
Published on: October 31, 2016
Association between methylation of SHP-1 isoform I and SSTR2A promoter regions with breast and prostate carcinoma
María Mercedes Tiscornia1, Heidi Soledad González, María Angélica Lorenzati
1Laboratory of Molecular Biotechnology, Faculty of Exact, Chemical and Natural Sciences, National University of Misiones , Posadas, Misiones , Argentina.
Abstract:
Methylation pattern is presented here for first time as a potential molecular marker of changes on SSTR2A and SHP-1(I) gene promoter related to breast and prostate carcinoma. Our results have shown low concordances with SSTR2A and methylated state in prostate cancer and moderate relationship with unmethylated CpG-27 in breast cancer. We found significant concordances for both cancers and SHP-1(I) unmethylation, and increased HER2 expression and SSTR2A methylation in breast cancer. Moreover, we found a correlation between methylation patterns of two genes in normal breast tissue. These data might assist to select subgroups of patients for the administration of alternative therapies.
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