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Immunity unmasks APOL1 in collapsing glomerulopathy
Bairbre A McNicholas1, Peter J Nelson1
1Division of Nephrology and Kidney Research Institute, University of Washington, Seattle, Washington, USA.
Kidney International
|January 31, 2015
Abstract:
Collapsing glomerulopathy predominantly afflicts patients of African ancestry, often first presenting after the immune system is engaged by another disorder. Nichols et al. now show that collateral induction of pathogenic APOL1 allelic variants in podocytes by the ongoing immune response may be the long-sought-after explanation for the development of collapsing glomerulopathy in these patients.
