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UVB erythema inhibited by topically applied substances
1Department of Dermatology, University of Oulu, Finland.
Acta Dermato-Venereologica
|January 1, 1989
Summary
Topical treatments like indomethacin and diphenhydramine can reduce UVB-induced skin redness when applied after sun exposure. Acetylsalicylic acid shows the best protective effect when applied shortly before UV exposure.
Area of Science:
- Dermatology
- Photobiology
- Pharmacology
Background:
- Ultraviolet B (UVB) radiation causes skin erythema.
- Photoprotective and antierythematous agents are crucial for skin health.
- Understanding application timing optimizes treatment efficacy.
Purpose of the Study:
- To evaluate the photoprotective and antierythematous effects of various topical agents.
- To determine the influence of application timing on UVB-induced erythema.
- To compare the efficacy of corticosteroids, acetylsalicylic acid (ASA), indomethacin (IM), butylhydroxytoluene (BHT), and diphenhydramine hydrochloride (DPH).
Main Methods:
- Healthy volunteers received UVB irradiation (3 x MED) on their backs.
- Test substances (corticosteroids, ASA, IM, BHT, DPH) in o/w creams were applied at different times (24h, 4h, 1h before; 1h, 4h after irradiation).
- Reactions were assessed visually and via laser Doppler flowmetry.
Main Results:
- ASA and IM significantly inhibited UVB erythema when applied before irradiation.
- IM, DPH, and potent corticosteroids reduced erythema when applied after irradiation; ASA, BHT, and hydrocortisone did not.
- 5% ASA demonstrated the greatest photoprotective effect when applied 4h or 1h prior to UVB exposure.
Conclusions:
- Topical indomethacin and diphenhydramine hydrochloride are effective in reducing UVB erythema post-irradiation.
- Acetylsalicylic acid provides significant photoprotection when applied shortly before UVB exposure.
- Application timing critically influences the antierythematous efficacy of tested topical agents.