Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hormonal Regulation01:33

Hormonal Regulation

37.5K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
37.5K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

4.6K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
4.6K
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

4
The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
4
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

1.7K
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
1.7K
Teratogenicity01:07

Teratogenicity

4.6K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.6K
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

1.1K
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transforming Preeclampsia Care: Molecular Diagnostics and Therapeutic Innovations.

Journal of the American Society of Nephrology : JASN·2026
Same author

Targeted removal of soluble Fms-like tyrosine kinase 1 in very preterm preeclampsia: a pilot trial.

Nature medicine·2026
Same author

Butyrophilin 2A2 promotes T cell immunoregulation via CD45 phosphatase activation and protects against murine autoimmune glomerulonephritis and pregnancy loss.

Nature communications·2026
Same author

Pointing Care for Preeclampsia in the Right Direction.

Hypertension (Dallas, Tex. : 1979)·2025
Same author

Serum soluble-fms-like tyrosine kinase 1-to-placental growth factor ratio on Elecsys immunoassay platform predicts preeclampsia with severe features in hospitalized women with hypertensive disorders of pregnancy.

American journal of obstetrics and gynecology·2025
Same author

Lipid-delivery system could treat life-threatening pregnancy complication.

Nature·2024

Related Experiment Video

Updated: Apr 18, 2026

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
05:31

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

1.5K

Pathogenesis of preeclampsia.

Monica Sircar1, Ravi Thadhani, S Ananth Karumanchi

  • 1aMassachusetts General Hospital and Harvard Medical School bBeth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.

Current Opinion in Nephrology and Hypertension
|January 31, 2015
PubMed
Summary

Preeclampsia, a kidney disease in pregnancy, involves endothelial injury and can lead to severe complications. New research focuses on soluble vascular factors for improved diagnostics and therapeutics.

More Related Videos

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

12.0K
A Plate-based Cytotoxicity Assay for the Assessment of Rat Placental Natural Killer Cell Cytolytic Function
10:44

A Plate-based Cytotoxicity Assay for the Assessment of Rat Placental Natural Killer Cell Cytolytic Function

Published on: June 2, 2019

6.4K

Related Experiment Videos

Last Updated: Apr 18, 2026

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
05:31

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

1.5K
Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

12.0K
A Plate-based Cytotoxicity Assay for the Assessment of Rat Placental Natural Killer Cell Cytolytic Function
10:44

A Plate-based Cytotoxicity Assay for the Assessment of Rat Placental Natural Killer Cell Cytolytic Function

Published on: June 2, 2019

6.4K

Area of Science:

  • Obstetrics and Gynecology
  • Nephrology
  • Vascular Biology

Background:

  • Preeclampsia is a serious gestational kidney disease marked by glomerular endothelial injury, causing hypertension and proteinuria.
  • Severe preeclampsia can result in hepatic and neurologic dysfunction, posing risks to both mother and fetus.
  • While initially managed by obstetricians, the progression of preeclampsia often necessitates nephrology consultation due to complications like acute kidney injury and refractory hypertension.

Purpose of the Study:

  • This review summarizes recent literature on the pathogenesis of preeclampsia.
  • It highlights emerging diagnostic and therapeutic strategies for managing this condition.
  • The focus is on understanding the role of soluble vascular factors in preeclampsia.

Main Methods:

  • Review of recent scientific literature on preeclampsia.
  • Analysis of studies investigating the role of soluble vascular factors.
  • Examination of newly developed therapeutics targeting angiogenic factors.

Main Results:

  • Over the past decade, soluble vascular factors have illuminated the mechanisms of preeclampsia.
  • Recent therapeutics targeting factors like soluble fms-like tyrosine kinase 1 (an endogenous vascular endothelial growth factor inhibitor) have been developed.
  • Serum levels of angiogenic factors correlate with hemodynamic and pathophysiologic changes, suggesting diagnostic and prognostic utility.

Conclusions:

  • Understanding of preeclampsia has advanced significantly.
  • The future of preeclampsia management holds promise for novel diagnostics and therapeutics based on disease mechanisms.
  • Targeting circulating angiogenic factors represents a key area for future development.