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Updated: Apr 18, 2026

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Published on: October 17, 2025

NMDA receptor dysfunction in autism spectrum disorders.

Eun-Jae Lee¹, Su Yeon Choi², Eunjoon Kim³

¹Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Republic of Korea.

Current Opinion in Pharmacology

|January 31, 2015

Summary

This summary is machine-generated.

Imbalances in neuronal excitation and inhibition, particularly involving NMDA receptors (NMDARs), are linked to autism spectrum disorders (ASDs). Correcting NMDAR dysfunction shows therapeutic potential for ASDs.

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Area of Science:

Neuroscience
Synaptic Plasticity
Neuropsychiatric Disorders

Background:

Neuronal excitatory and inhibitory synapse imbalances are implicated in neuropsychiatric disorders like autism spectrum disorders (ASDs).
NMDA receptor (NMDAR) dysfunction at excitatory synapses is increasingly associated with ASDs.
Genetic variations linked to ASDs are found in genes encoding NMDAR subunits.

Purpose of the Study:

To investigate the role of NMDA receptor (NMDAR) dysfunction in autism spectrum disorders (ASDs).
To explore the therapeutic potential of correcting NMDAR dysfunction in ASDs.

Main Methods:

Review of genetic variations associated with ASDs and NMDAR subunit genes.
Analysis of pharmacological interventions targeting NMDAR function in humans with ASDs.
Examination of NMDAR function in animal models of ASD and behavioral rescue.

Main Results:

Human genetic variations in NMDAR subunit genes are linked to ASDs.
Modulating NMDAR function pharmacologically improves ASD symptoms in humans.
Bidirectional NMDAR dysfunction in ASD animal models is associated with ASD-like behaviors, and correction rescues these behaviors.

Conclusions:

NMDAR dysfunction, in either direction, contributes to the development of ASDs.
Targeting NMDAR function represents a potential therapeutic strategy for ASDs.