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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

2
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
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Brain Imaging01:14

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A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
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Altered thalamic functional connectivity in multiple sclerosis.

Yaou Liu1, Peipeng Liang1, Yunyun Duan1

  • 1Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, PR China.

European Journal of Radiology
|February 1, 2015
PubMed
Summary
This summary is machine-generated.

Multiple sclerosis (MS) patients show altered brain connectivity, with decreased thalamus-to-cortex connections but increased thalamus-to-thalamus connections. These functional changes may reflect adaptations that diminish with disease duration.

Keywords:
Brain plasticityFunctional connectivityFunctional impairmentMultiple sclerosisResting-state functional MRIThalamus

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Area of Science:

  • Neuroimaging
  • Neurology
  • Functional Connectivity Analysis

Background:

  • Multiple sclerosis (MS) is a demyelinating disease affecting the central nervous system.
  • The thalamus plays a crucial role in relaying sensory and motor signals to the cerebral cortex.
  • Understanding functional connectivity (FC) alterations in the thalamus is vital for comprehending MS pathophysiology.

Purpose of the Study:

  • To compare thalamic functional connectivity (FC) between patients with MS and healthy controls (HC).
  • To investigate the relationship between thalamic FC and MRI metrics (thalamic volume, T2 lesion volume) and clinical variables (EDSS, disease duration).

Main Methods:

  • Resting-state functional MRI (fMRI) was used to assess FC in 35 MS patients and 35 HC.
  • Thalamic FC was analyzed by correlating fMRI signal fluctuations between thalamic voxels and all other brain regions.
  • Thalamic volume fraction (TF), T2 lesion volume (T2LV), EDSS, and disease duration were recorded.

Main Results:

  • MS patients exhibited significantly lower thalamic volume fraction (TF) compared to HC.
  • Decreased FC was observed between the thalamus and specific cortical regions (e.g., middle frontal gyrus) in MS patients.
  • Increased intra- and inter-thalamic FC were found in MS patients, negatively correlating with disease duration (r=-0.59, p<0.001).

Conclusions:

  • MS patients display complex alterations in thalamic connectivity, including reduced cortical and enhanced intra/inter-thalamic connections.
  • These functional changes are largely independent of lesion load and thalamic atrophy.
  • The decline in inter-thalamic connectivity with disease duration suggests a potential adaptive mechanism that is gradually lost over time.