Genetically engineered mouse models to study prostate cancer

Area of Science:

• Oncology
• Genetics
• Translational Research

Background:

• Genetically engineered mouse models (GEMMs) are essential for prostate cancer research.
• Numerous GEMMs exist to study genetic alterations and signaling pathways in prostate cancer.
• These models are vital for developing and testing novel, personalized therapies.

Purpose of the Study:

• To discuss current and recent genetically engineered mouse models for in vivo prostate cancer research.
• To provide guidance on selecting appropriate models for specific research questions.
• To outline methods for prostate tumor isolation, characterization, and sample processing.

Main Methods:

• Review of existing literature on prostate cancer GEMMs.
• Description of techniques for isolating and characterizing prostate tumors.
• Discussion of sample processing for downstream analyses.

Main Results:

• A comprehensive overview of available GEMMs for prostate cancer research.
• Considerations for choosing the most suitable model based on research objectives.
• Standardized methods for basic tumor characterization (load, histopathology).

Conclusions:

• GEMMs are indispensable tools for advancing prostate cancer basic and translational research.
• Careful model selection and standardized analytical methods are critical for robust study outcomes.
• This chapter serves as a guide for researchers utilizing GEMMs in prostate cancer studies.