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Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Related Experiment Video

Updated: Apr 18, 2026

Live Imaging of Drug Responses in the Tumor Microenvironment in Mouse Models of Breast Cancer

Live Imaging of Drug Responses in the Tumor Microenvironment in Mouse Models of Breast Cancer

Published on: March 24, 2013

Tumor imaging technologies in mouse models.

Michael Bouvet¹, Robert M Hoffman

¹Department of Surgery, University of California San Diego, Moores Cancer Center, 3855 Health Sciences Drive #0987, La Jolla, CA, 92093-0987, USA, mbouvet@ucsd.edu.

Methods in Molecular Biology (Clifton, N.J.)

|February 1, 2015

Summary

This summary is machine-generated.

This study presents advanced mouse models for cancer research using fluorescent proteins (GFP, RFP) for real-time tumor imaging. These models enable visualization of tumor growth and metastasis, aiding the development of new cancer therapies.

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Last Updated: Apr 18, 2026

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Multianimal Magnetic Resonance Imaging for Tumor Measurements in Pancreatic Cancer Mouse Models

Multianimal Magnetic Resonance Imaging for Tumor Measurements in Pancreatic Cancer Mouse Models

Published on: February 3, 2026

Area of Science:

Oncology
Biotechnology
Medical Imaging

Background:

Developing accurate preclinical models for human cancer is crucial for therapeutic development.
Existing imaging techniques can be limited by invasiveness, cost, or need for contrast agents.

Purpose of the Study:

To describe protocols for novel tumor imaging technologies in mouse models.
To establish reliable in vivo models for studying cancer progression and metastasis.
To demonstrate the utility of fluorescence imaging for evaluating novel therapeutic strategies.

Main Methods:

Genetically engineered human cancer cell lines expressing fluorescent proteins (GFP, RFP).
Subcutaneous and orthotopic tumor implantation in nude mice.
Real-time, high-resolution fluorescence imaging of tumor growth and metastasis in vivo.
Utilizing fluorescently labeled tumor cells to visualize tumor-host interactions.

Main Results:

Established models allowing spontaneous and rapid tumor growth and metastasis.
Achieved specific, high-resolution, real-time quantitative fluorescence imaging without contrast agents.
Visualized tumor-host interactions, including stroma and vasculature, in pancreatic cancer models.
Demonstrated real-time antitumor and antimetastatic effects of novel therapeutic strategies.

Conclusions:

Fluorescence imaging in mouse models provides a powerful, non-invasive tool for cancer research.
These models are effective for investigating metastatic human cancer and testing new therapies.
Fluorescence imaging complements other modalities like MRI and ultrasound.