Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Parkinson's disease.

E C Wolters1, D B Calne

  • 1Department of Medicine, University Hospital, Vancouver, BC.

CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne
|March 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The cardiovascular effects of bromocriptine in Parkinsonism.

British journal of clinical pharmacology·2012
Same author

Parkinsonism-physiology and pharmacology.

British medical journal·2010
Same author

German-Canadian family (family A) with parkinsonism, amyotrophy, and dementia - Longitudinal observations.

Parkinsonism & related disorders·2008
Same author

The role of the Lewy body in idiopathic Parkinsonism.

Parkinsonism & related disorders·2008
Same author

Mental dysfunction in Parkinson's disease.

Parkinsonism & related disorders·2008
Same author

Slowing of oscillatory brain activity is a stable characteristic of Parkinson's disease without dementia.

Brain : a journal of neurology·2007
Same journal

Rheumatoid synovitis of the elbow mimicking rheumatoid nodule.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne·2026
Same journal

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne·2026
Same journal

What pool closures in Canada mean for health.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne·2026
Same journal

Fatal rabies in a child.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne·2026
Same journal

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne·2026
Same journal

Otitis externa.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne·2026
See all related articles

Parkinson's disease involves dopamine neuron loss, causing tremors and rigidity. Current treatments offer palliative relief, with ongoing research into neuroprotective drugs and cell transplants for Parkinson's disease management.

Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Parkinson's disease is characterized by substantia nigra neuron degeneration and dopamine depletion.
  • Clinical hallmarks include tremor, rigidity, and bradykinesia.

Purpose of the Study:

  • To review current palliative therapies for Parkinson's disease.
  • To discuss potential disease-modifying treatments and novel therapeutic strategies.

Main Methods:

  • Review of existing literature on Parkinson's disease pharmacotherapy.
  • Analysis of drug categories: anticholinergic agents, dopamine precursors, and dopamine agonists.
  • Exploration of emerging treatments like selective agonists and cell transplantation.

Main Results:

  • Current treatments primarily manage symptoms, not disease progression.

Related Experiment Videos

  • Evidence for disease-slowing drugs remains limited.
  • Individualized treatment plans and careful dosage titration are crucial.

    • Conclusions:

    • Parkinson's disease pharmacotherapy requires personalized approaches.
    • New developments, including advanced drug formulations and cell-based therapies, offer future treatment avenues.
    • Managing Parkinson's disease remains a complex pharmacological challenge.