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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Special considerations of antibiotic prescription in the geriatric population
C L Beckett1, S Harbarth2, B Huttner2
1Infectious Diseases Department, Eastern Health, Victoria, Australia.
Abstract:
Infectious diseases pose a major challenge in the elderly for two reasons: on the one hand the susceptibility to infection increases with age and when infections occur they often present atypically-on the other hand diagnostic uncertainty is much more pronounced in the geriatric population. Reconciling the opposing aspects of optimizing patient outcomes while avoiding antibiotic overuse requires significant expertise that can be provided by an infectious diseases consultant. In addition, geriatric facilities are reservoirs for multidrug-resistant organisms and other nosocomial pathogens, and infectious diseases consultants also play a vital role in assuring appropriate infection control measures. In this review we outline the challenges of diagnosis and management of infectious diseases in the elderly, and discuss the importance of appropriate antibiotic use in the elderly in order to demonstrate the value of the infectious diseases consultant in this special setting.
Insights
Elderly individuals face increased infection risk and atypical symptoms, complicating diagnosis and treatment. Infectious diseases consultants are crucial for optimizing care and infection control in geriatric settings.
Area of Science:
- Geriatric Medicine
- Infectious Diseases
- Public Health
Background:
- Aging increases susceptibility to infections and leads to atypical presentations.
- Geriatric populations experience significant diagnostic uncertainty in infectious diseases.
- Geriatric facilities harbor multidrug-resistant organisms and nosocomial pathogens.
Purpose of the Study:
- To outline diagnostic and management challenges of infectious diseases in the elderly.
- To discuss the importance of judicious antibiotic use in geriatric patients.
- To demonstrate the value of infectious diseases consultants in geriatric care.
Main Methods:
- Review of current literature on infectious diseases in the elderly.
- Analysis of challenges in diagnosis and management.
- Discussion of antibiotic stewardship principles.
Main Results:
- Infections in the elderly present atypically, increasing diagnostic difficulty.
- Optimizing outcomes while preventing antibiotic overuse requires specialized expertise.
- Infectious diseases consultants are vital for infection control in geriatric facilities.
Conclusions:
- Infectious diseases consultants are essential for managing infections in the elderly.
- Appropriate antibiotic use is critical to combat resistance and improve patient outcomes.
- Specialized infectious diseases consultation enhances care in geriatric settings.
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