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Generalized model of electromigration with 1:1 (analyte:selector) complexation stoichiometry: part I. Theory
Pavel Dubský1, Ludmila Müllerová1, Martin Dvořák1
1Charles University in Prague, Faculty of Science, Department of Physical and Macromolecular Chemistry, Prague, Czech Republic.
Journal of Chromatography. A
|February 1, 2015
Summary
A new electromigration model simplifies the analysis of multivalent analytes complexing with multiple selectors. This advancement aids in developing analytical electrophoresis methods, particularly for enantioseparations.
Area of Science:
- Analytical Chemistry
- Physical Chemistry
Background:
- Electromigration models have evolved to describe analyte complexation.
- Previous models addressed single selectors and monovalent or non-dissociating analytes.
Purpose of the Study:
- To introduce a comprehensive model for electromigration of multivalent weak analytes with multiple selectors.
- To extend existing electromigration theories for complex analytical scenarios.
Main Methods:
- Development of a new mathematical model for multivalent weak analyte complexation.
- Mathematical demonstration of parameter integration between multi-selector and pH-dependent models.
Main Results:
- The model shows effective analyte mobility follows Wren and Rowe's original formula.
- Overall complexation constants and mobilities of free analyte and complex are measurable.
- pH-dependent parameters can be integrated into the multi-selector model and vice versa.
Conclusions:
- The new model simplifies the development of analytical electrophoresis methods.
- It offers a unified approach for analyzing complex analyte-selector interactions.
- Facilitates rational method development, especially for enantioseparations.
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