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Published on: December 15, 2011
CD103+ γδ T cell large granular lymphocytosis in a patient with refractory celiac disease: a diagnostic enigma
Sreejesh Sreedharanunni1, Neelam Varma, Man Updesh Singh Sachdeva
1Department of Hematology, Post Graduate Institute of Medical Education and Research (PGIMER), V Floor, SS Anand Block (Research Block A), Chandigarh, 160012, India, dr.s.sreejesh@gmail.com.
Abstract:
Indolent γδ T cell lymphomas/leukemias are rare and overlap with the morphological spectrum of large granular lymphocyte (LGL) leukemia. We report an extremely rare case of CD103(+) γδ T LGL leukemia in a patient with celiac disease who presented with refractory diarrhea. Whether the refractory diarrhea in our patient was a manifestation of LGL leukemia itself or whether the clonal LGL expansion is a manifestation of refractory celiac disease (RCD) remains an enigma. This report highlights the diagnostic difficulties and the need of consensus in categorizing clonal CD103(+) lymphocytosis in patients with RCD.

