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Incidence and risk of xerosis with targeted anticancer therapies

Johannah Valentine1, Viswanath Reddy Belum2, Juanita Duran3

  • 1Department of Dermatology, Naval Medical Center San Diego, San Diego, California.

Journal of the American Academy of Dermatology
|February 1, 2015
PubMed
Abstract

Insights

Targeted cancer therapies significantly increase the risk of xerosis (dry skin). This systematic review found a 17.9% incidence, highlighting the need for early patient counseling and treatment to maintain quality of life.

Area of Science:

  • Oncology
  • Dermatology
  • Clinical Pharmacology

Background:

  • Targeted cancer therapies are associated with xerosis (dry skin).
  • The precise incidence and relative risk of xerosis from these treatments remain unclear.

Purpose of the Study:

  • To systematically review and meta-analyze clinical trials.
  • To determine the incidence and risk of xerosis in patients receiving anticancer drugs.

Main Methods:

  • Searched PubMed, Web of Science, and ASCO abstracts (1966-2013).
  • Included clinical trials involving 58 targeted anticancer agents.
  • Utilized random or fixed effects models for results calculation.

Main Results:

  • Overall incidence of xerosis was 17.9% (95% CI: 15.6-20.4%).
  • High-grade xerosis incidence was 1.0% (95% CI: 0.9-1.5%).
  • The risk of developing any-grade xerosis was 2.99 (95% CI: 2.0-4.3), varying by drug.

Conclusions:

  • Patients on targeted therapies face a significant risk of xerosis.
  • Xerosis reporting may be inconsistent.
  • Early patient counseling and treatment are crucial for managing xerosis, preventing dose reduction, and preserving quality of life.
Keywords:
Bcr-AblCD20CD52EGFRHDACHER2MEKRafVEGFRdry skinincidencemTORriskxerosis

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