Purinergic signaling in atherosclerosis

Area of Science:

• Biochemistry
• Molecular Biology
• Cardiovascular Research

Background:

• Extracellular nucleotides (ATP, ADP, UTP, adenosine) act as signaling molecules via cell surface receptors and ecto-nucleotidases.
• These nucleotides are involved in various physiological and pathological processes, including tissue stress and damage.

Purpose of the Study:

• To summarize recent findings on the role of the purinergic signaling network in the development and progression of atherosclerosis.
• To highlight the dual role of purinergic signaling in atherosclerosis, with protective effects from adenosine and P1 receptors, and pro-atherosclerotic effects from P2 receptors.

Main Methods:

• Literature review and synthesis of recent research data.
• Analysis of the involvement of purinergic signaling components (receptors, ecto-nucleotidases) in atherogenesis.

Main Results:

• Adenosine, most P1 receptors, and ecto-nucleotidases generally exhibit a protective, anti-atherosclerotic function.
• P2 receptors, conversely, have been shown to promote atherosclerosis.
• The purinergic network plays a significant role in both the formation and evolution of atheroma.

Conclusions:

• Modulating purinergic signaling represents a potential innovative therapeutic strategy to combat atherosclerosis.
• Understanding the specific roles of different purinergic components is crucial for developing targeted interventions.