Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Statistical Software for Data Analysis and Clinical Trials01:12

Statistical Software for Data Analysis and Clinical Trials

1.9K
Statistical software is pivotal in data analysis and clinical trials by providing tools to analyze data, draw conclusions, and make predictions. These software packages range from simple data management applications to complex analytical platforms, supporting various statistical tests, models, and simulation techniques. Their significance lies in their ability to handle vast amounts of data with precision and efficiency, enabling researchers to validate hypotheses, identify trends, and make...
1.9K
Biostatistics: Overview01:20

Biostatistics: Overview

1.2K
Biostatistics plays a crucial role in understanding and analyzing data in healthcare and biology. Biostatisticians conduct experiments, gather evidence, and draw meaningful conclusions using statistical methods and techniques. Different variables form the foundation of biostatistical analysis, allowing researchers to understand and interpret data effectively. These variables are classified into different types, each serving a specific purpose in statistical analysis.
Discrete variables are...
1.2K
Synthetic Biology02:55

Synthetic Biology

5.8K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
5.8K
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

7.3K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
7.3K
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models01:06

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

320
Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
320

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quantifying domain-specific relevance of computational biology Wikipedia articles using TF-IDF and cosine similarity.

Bioinformatics (Oxford, England)·2026
Same author

Autologous macrophage therapy increases transplant-free survival in cirrhosis: Long-term follow-up of a phase 2 clinical trial.

Cell stem cell·2026
Same author

Prediction of Acute Liver Injury Trajectory in Patients Following Acetaminophen Overdose: A Multibiomarker Machine Learning Proof-of-Concept Study.

Clinical pharmacology and therapeutics·2026
Same author

Disordered Bile Acid Metabolism in Alcohol-Related Hepatitis.

Alimentary pharmacology & therapeutics·2026
Same author

MC1R determines healing outcomes in acute and chronic cutaneous wounds.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Impact of the COVID-19 pandemic on computational biology early career researchers: A global retrospective study.

PLoS computational biology·2025

Related Experiment Video

Updated: Apr 18, 2026

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
10:44

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

Published on: December 7, 2021

2.7K

Dizzy-Beats: a Bayesian evidence analysis tool for systems biology.

Stuart Aitken1, Alastair M Kilpatrick2, Ozgur E Akman1

  • 1MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh EH4 2XU, UK, School of Informatics, University of Edinburgh, Edinburgh EH8 9AB, UK, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA, Centre for Systems, Dynamics and Control, College of Engineering, Mathematics & Physical Sciences, University of Exeter, Exeter EX4 4QF, UK.

Bioinformatics (Oxford, England)
|February 1, 2015
PubMed
Summary

Dizzy-Beats, a new tool, aids systems biology by estimating Bayesian evidence and model parameters using nested sampling. This simplifies complex model selection and parameter inference challenges in biological systems analysis.

More Related Videos

A Web Tool for Generating High Quality Machine-readable Biological Pathways
08:01

A Web Tool for Generating High Quality Machine-readable Biological Pathways

Published on: February 8, 2017

18.7K
A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information
05:01

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information

Published on: July 1, 2020

3.9K

Related Experiment Videos

Last Updated: Apr 18, 2026

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
10:44

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

Published on: December 7, 2021

2.7K
A Web Tool for Generating High Quality Machine-readable Biological Pathways
08:01

A Web Tool for Generating High Quality Machine-readable Biological Pathways

Published on: February 8, 2017

18.7K
A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information
05:01

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information

Published on: July 1, 2020

3.9K

Area of Science:

  • Systems Biology
  • Computational Biology
  • Bioinformatics

Background:

  • Model selection and parameter inference are critical yet complex challenges in systems biology.
  • Uncertainty in biochemical mechanisms necessitates evaluating alternative models.
  • Parameter inference quantifies data and model constraints on parameter values.

Purpose of the Study:

  • To introduce Dizzy-Beats, a novel graphical Java tool for Bayesian evidence analysis.
  • To address challenges in systems modeling, specifically model selection and parameter inference.
  • To provide an efficient method for estimating Bayesian evidence and parameter moments.

Main Methods:

  • Implementation of nested sampling algorithm for Bayesian evidence estimation.
  • Utilisation of a graphical Java interface for user-friendly analysis.
  • Adoption of an L1-norm based likelihood function for broad applicability.

Main Results:

  • Dizzy-Beats provides estimates of the log of the Bayesian evidence (Z).
  • The tool calculates moments of model parameters, aiding inference.
  • The L1-norm likelihood function is suitable for replicated time series data.

Conclusions:

  • Dizzy-Beats offers a robust solution for complex systems biology modeling tasks.
  • The tool facilitates improved model selection and parameter inference.
  • Nested sampling, as implemented, effectively addresses key challenges in systems modeling.