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Related Experiment Video

Updated: Apr 18, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

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Published on: June 24, 2020

Maternal microchimerism: lessons learned from murine models.

Ina Annelies Stelzer¹, Kristin Thiele¹, Maria Emilia Solano¹

¹Laboratory of Experimental Feto-Maternal Medicine, University Medical Center Hamburg-Eppendorf, Germany.

Journal of Reproductive Immunology

|February 2, 2015

Summary

Maternal microchimerism (MMc), where maternal cells persist in offspring, may act as a messenger shaping immunity. Mouse models are crucial for studying MMc

Keywords:

Fetal immune ontogeny Feto-maternal immune cross-talk In utero programming Maternal microchimerism Mouse pregnancy

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Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Published on: May 21, 2015

Area of Science:

Reproductive immunology and developmental biology.

Background:

Maternal microchimerism (MMc) involves maternal cells persisting in offspring post-pregnancy.
MMc is acquired physiologically and can impact offspring health and disease.
Mouse models are vital for studying MMc due to limitations in human tissue research.

Purpose of the Study:

To review detection techniques and experimental designs in murine MMc research.
To summarize MMc migration, distribution, function, and modulating factors.
To propose MMc as a materno-fetal messenger influencing offspring immunity.

Main Methods:

Compilation of existing murine MMc research.
Analysis of MMc detection techniques and experimental settings.
Review of studies on MMc migration, distribution, and function.

Main Results:

MMc can be detected using various methods in mouse models.
MMc exhibits specific tissue distribution patterns and functional consequences.
Factors influencing MMc occurrence and persistence have been identified.

Conclusions:

MMc plays a role in shaping offspring development, particularly immunity.
Further research using mouse models is essential to understand MMc's functional impact.
MMc represents a significant materno-fetal communication pathway.