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Automated Preparation of [68Ga]Ga-3BP-3940 on a Synthesis Module for PET Imaging of the Tumor Microenvironment
Published on: April 25, 2025
Cation exchange-based post-processing of (68)Ga-eluate: a comparison of three solvent systems for labelling of
Johanna Seemann1, Elisabeth Eppard1, Bradley P Waldron1
1Institute of Nuclear Chemistry, Johannes Gutenberg University Mainz, 55128 Mainz, Germany.
Abstract:
Interest in (68)Ga has led to a number of innovations for its provision suitable for clinical application. Several post-processing methods are available to reduce eluate volume and remove metal trace impurities. In this work three cation exchange resin based post-processing methods (acetone, ethanol and NaCl) have been compared, using three model precursors (DOTATOC, NO2AP(BP) and DATA(m)), in terms of labelling yield and reproducibility. The acetone and ethanol based methods provided greater reproducibility and yields that makes subsequent purification unnecessary.
