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Intractable nodulocystic acne in a patient with trisomy 13

Jenna M Peart1, Daniel J Licht1,2,3, Erin O'Connor Prange2,3

  • 1Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Pediatric Dermatology
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Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
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