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Enzyme and voltage stimuli-responsive controlled release system based on β-cyclodextrin-capped mesoporous silica
1State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun, China. huoqisheng@jlu.edu.cn.
Dalton Transactions (Cambridge, England : 2003)
|February 3, 2015
Summary
This study developed novel nanovalves using mesoporous silica nanoparticles functionalized with ferrocene and beta-cyclodextrin. These nanovalves offer controlled release triggered by enzymes or voltage stimuli.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Stimuli-Responsive Systems
Background:
- Stimuli-responsive systems are crucial for controlled release applications.
- Ferrocene (Fc) and beta-cyclodextrin (β-CD) inclusion complexes offer unique responsive mechanisms.
- Mesoporous silica nanoparticles (MSNs) provide a versatile platform for drug delivery.
Purpose of the Study:
- To engineer MSNs with ferrocene and β-CD to create a nanovalve-based release system.
- To investigate the controlled release capabilities of the nanovalves in response to biological and electrical stimuli.
- To demonstrate the potential for tunable release by modulating enzyme concentration or voltage.
Main Methods:
- Functionalization of MSNs with ferrocenyl moieties.
- Formation of β-CD/Fc inclusion complexes to act as nanovalves.
- Stimulation of release using enzymes (heme proteins, GOD/HRP) and electrochemical oxidation (+1.5 V).
- Characterization of the release kinetics under different conditions.
Main Results:
- Successful development of MSNs with β-CD/Fc nanovalves.
- Demonstrated stimuli-responsive release triggered by specific enzymes and voltage.
- Achieved controlled release by adjusting enzyme amounts or applied voltage.
- The nanovalve system showed sensitivity to heme proteins, H2O2, glucose, and electrochemical oxidation.
Conclusions:
- The developed nanovalve system offers a promising platform for controlled release applications.
- Enzyme and voltage stimuli provide biologically compatible triggers for the release system.
- The system allows for tunable and precise control over the release rate.
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