Biological stimuli-responsive cyclodextrin-based host-guest nanosystems for cancer therapy

Area of Science:

• Nanomedicine
• Biomedical Engineering
• Cancer Therapeutics

Background:

• Stimuli-responsive nanosystems are crucial for targeted cancer therapy, enabling drug release via tumor microenvironment triggers like pH, redox, and enzymes.
• Cyclodextrin (CD)-based host-guest interactions offer a versatile platform for designing advanced multifunctional nanosystems.
• Current research focuses on developing intelligent drug delivery systems for enhanced cancer treatment outcomes.

Purpose of the Study:

• To review the progress of cyclodextrin-based host-guest nanosystems (CHNs) with biological stimuli-responsive properties for cancer therapy.
• To summarize the composition, structure, and design strategies of CHNs that respond to tumor-specific stimuli.
• To evaluate the performance of these CHNs in controlled drug delivery and cancer treatment.

Main Methods:

• Literature review of stimuli-responsive CD-based host-guest nanosystems.
• Analysis of CHN composition, structure, and design principles.
• Evaluation of CHN performance in preclinical cancer models and drug delivery studies.

Main Results:

• Various CHNs have been designed to respond to specific tumor microenvironment stimuli.
• These CHNs demonstrate controlled drug release capabilities, enhancing therapeutic delivery.
• The intelligent design of CHNs improves overall anticancer efficacy.

Conclusions:

• CD-based host-guest nanosystems represent a promising approach for stimuli-responsive cancer therapy.
• These nanosystems offer precise control over drug release, targeting tumor-specific conditions.
• Further development of CHNs holds significant potential for advancing intelligent cancer drug delivery systems.