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Can QT/RR relationship differentiate between low- and high-risk patients with hypertrophic cardiomyopathy?

Ricardo A Quinteiro1, Marcelo O Biagetti1, Adrian Fernandez2

  • 1Cardiac Electrophysiology Laboratory, Favaloro University, Buenos Aires, Argentina.

Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
|February 3, 2015
PubMed

Insights

QT dynamicity, a measure of heart repolarization, is impaired in hypertrophic cardiomyopathy (HCM) patients. This metric may help distinguish between low- and high-risk individuals with HCM.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Medical Diagnostics

Background:

  • Abnormal repolarization dynamicity is linked to myocardial vulnerability and increased risk of sudden cardiac death.
  • Limited data exists on QT interval dynamics in hypertrophic cardiomyopathy (HCM).

Purpose of the Study:

  • To assess ventricular repolarization using QT dynamicity in HCM patients.
  • To determine if QT dynamicity can differentiate between low- and high-risk HCM patients.

Main Methods:

  • Calculated linear regression slopes (QTapex/RR and QTend/RR) from 24-hour Holter recordings.
  • Analyzed data from 36 HCM patients and 64 control subjects.

Main Results:

  • HCM patients exhibited significantly steeper QTapex/RR and QTend/RR slopes compared to controls.
  • High-risk HCM patients showed steeper QTend/RR and QTapex/RR slopes than controls.
  • QTend/RR slopes significantly differed between low- and high-risk HCM groups.

Conclusions:

  • QT dynamicity appears impaired in HCM patients.
  • QT dynamicity may serve as a tool to stratify risk in HCM.
  • Further research is needed to clarify the prognostic value of impaired ventricular repolarization in HCM.
Abstract

Keywords:
noninvasive techniques-Holter/event recordersnoninvasive techniques-QT dispersion

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