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A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
Published on: May 22, 2019
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Depression, anxiety, and cognitive functioning after intracerebral hemorrhage
R-J Koivunen1, H Harno1, T Tatlisumak1
1Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland.
Acta Neurologica Scandinavica
|February 3, 2015
Summary
Long-term post-stroke depression (PSD) affects nearly a quarter of young intracerebral hemorrhage (ICH) survivors. Higher disability levels predict depression, highlighting an unmet treatment need in this population.
Area of Science:
- Neurology
- Psychiatry
- Stroke Medicine
Background:
- Post-stroke depression (PSD) is a significant complication following cerebrovascular events.
- Intracerebral hemorrhage (ICH) in young individuals presents unique long-term challenges.
- Understanding the prevalence and predictors of PSD in young ICH survivors is crucial for effective management.
Purpose of the Study:
- To investigate the long-term incidence of post-stroke depression (PSD) in young survivors of intracerebral hemorrhage (ICH).
- To assess anxiety levels and cognitive functioning in this patient cohort.
- To identify factors associated with the development of long-term PSD.
Main Methods:
- A cohort of 336 young ICH patients (age 16-49) was analyzed.
- Long-term follow-up (median 9.7 years) included interviews with 130 survivors using validated questionnaires (BDI-II, HADS, PASS, BPI, MoCA).
- Statistical analyses identified factors associated with PSD (BDI-II >13) and disability (mRS).
Main Results:
- PSD was diagnosed in 23.1% and anxiety in 40.0% of survivors.
- Higher disability scores correlated significantly with depression, emotional distress, and pain.
- Hydrocephalus was the sole baseline predictor of PSD; cognitive function was generally preserved.
Conclusions:
- Approximately one in four young ICH survivors experience long-term PSD.
- Increased physical disability is a significant predictor of developing PSD.
- There is a clear unmet need for depression treatment in young ICH survivors.
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