Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Extracellular Matrix01:42

The Extracellular Matrix

91.4K
Overview
91.4K
The Extracellular Matrix01:29

The Extracellular Matrix

13.8K
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
13.8K
Extracellular Matrix01:26

Extracellular Matrix

6.8K
Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
6.8K
Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

3.8K
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
3.8K
Connective Tissue Fibers and Ground Substance01:17

Connective Tissue Fibers and Ground Substance

44.9K
One of the significant functions of connective tissue is connecting tissues and organs. Unlike epithelial tissue that is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. The matrix usually includes a large amount of extracellular material produced by the connective tissue cells that are embedded within it. It plays a significant role in the functioning of this tissue. The major component of the matrix is a...
44.9K
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

10.0K
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
10.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Collagen fibril formation at the plasma membrane occurs independently from collagen secretion.

Wellcome open research·2025
Same author

Pulsatile low shear stress increases susceptibility to endothelial inflammation via upregulation of IFT and activation of YAP.

APL bioengineering·2025
Same author

Engineering growth factor gradients to drive spatiotemporal tissue patterning in organ-on-a-chip systems.

Journal of tissue engineering·2025
Same author

Fibrillin-1 Deficiency Perturbs Aortic Cholinergic Relaxation and Adrenergic Contraction in a Mouse Model of Early Onset Progressively Severe Marfan Syndrome.

Journal of vascular research·2025
Same author

Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis.

eLife·2025
Same author

Collagen IV deficiency causes hypertrophic remodeling and endothelium-dependent hyperpolarization in small vessel disease with intracerebral hemorrhage.

EBioMedicine·2024

Related Experiment Video

Updated: Apr 18, 2026

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms
08:32

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms

Published on: March 22, 2024

2.0K

Tendon functional extracellular matrix.

Hazel R C Screen1, David E Berk, Karl E Kadler

  • 1Institute of Bioengineering, School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London, E1 4NS, United Kingdom.

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
|February 3, 2015
PubMed
Summary
This summary is machine-generated.

This review highlights the critical role of the tendon extracellular matrix in mechanical function and cellular signaling. Understanding cell-matrix interactions is key for advancing tendon healing and repair strategies.

Keywords:
cellcollagenhierarchymechanicsproteoglycansstructuretendinopathytenocyte

More Related Videos

Author Spotlight: Advancements in Cell and Tissue Engineering for Tendon Repair
04:48

Author Spotlight: Advancements in Cell and Tissue Engineering for Tendon Repair

Published on: March 1, 2024

2.6K
Author Spotlight: Advancing Tendon Tissue Engineering with 3D Organoid Models
03:35

Author Spotlight: Advancing Tendon Tissue Engineering with 3D Organoid Models

Published on: June 21, 2024

2.7K

Related Experiment Videos

Last Updated: Apr 18, 2026

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms
08:32

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms

Published on: March 22, 2024

2.0K
Author Spotlight: Advancements in Cell and Tissue Engineering for Tendon Repair
04:48

Author Spotlight: Advancements in Cell and Tissue Engineering for Tendon Repair

Published on: March 1, 2024

2.6K
Author Spotlight: Advancing Tendon Tissue Engineering with 3D Organoid Models
03:35

Author Spotlight: Advancing Tendon Tissue Engineering with 3D Organoid Models

Published on: June 21, 2024

2.7K

Area of Science:

  • Orthopaedic Research
  • Biomaterials Science
  • Cellular Biology

Background:

  • Tendon tissue is a complex network of extracellular matrix and cells.
  • Tendon biological functions are influenced by intrinsic and extrinsic factors like age, nutrition, exercise, and biomechanics.
  • Tendon dynamically adapts during development, aging, and injury.

Purpose of the Study:

  • To review workshop discussions from the "Functional Extracellular Matrix" stream at the Orthopaedic Research Society New Frontiers in Tendon Research Conference.
  • To summarize the identified roles of the tendon extracellular matrix.
  • To highlight key research directions for tendon healing and repair.

Main Methods:

  • Review of workshop discussions from a specialized conference stream.
  • Synthesis of expert views on extracellular matrix functions in tendons.
  • Identification of emerging research priorities.

Main Results:

  • The tendon extracellular matrix performs crucial mechanical functions.
  • The extracellular matrix shapes the local cellular environment and provides cellular cues.
  • Cell-matrix interactions are central to tendon adaptation and biological responses.

Conclusions:

  • Understanding cell-matrix interactions is paramount for developing novel therapeutic strategies.
  • Future research should focus on elucidating these interactions to improve tendon healing and repair.
  • Targeting cell-matrix communication offers promising avenues for orthopaedic interventions.