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Metabolomic applications in nutritional research: a perspective.
Aoife O'Gorman1, Lorraine Brennan1,2
1UCD School of Agriculture and Food Science, Institute of Food and Health, UCD Conway Institute, Belfield, Dublin 4, Ireland.
Journal of the Science of Food and Agriculture
|February 3, 2015
Summary
Metabolomics, the study of metabolites, is increasingly used in nutrition research. Applications include identifying dietary biomarkers, understanding diet-related diseases, and evaluating nutritional interventions.
Area of Science:
- Metabolomics
- Nutritional Science
- Biochemistry
Background:
- Metabolomics globally studies metabolites in biological systems.
- Analytical techniques like NMR spectroscopy and mass spectrometry (MS) enable metabolic perturbation analysis.
- Metabolism and nutrition are closely linked, driving metabolomics applications in nutritional research.
Purpose of the Study:
- To provide an overview of metabolomics applications in nutritional research.
- To categorize current uses of metabolomics in nutrition.
- To offer an outlook on the future of metabolomics in this field.
Main Methods:
- Utilizing Nuclear Magnetic Resonance (NMR) spectroscopy.
- Employing hyphenated Mass Spectrometry (MS).
- Applying advanced multivariate statistical methods.
Main Results:
- Metabolomics applications in nutrition fall into three main categories:
- Dietary biomarker identification.
- Understanding diet-related diseases.
- Evaluating nutritional interventions.
Conclusions:
- Metabolomics is a valuable tool in nutritional research.
- Its applications are expanding in dietary biomarker discovery, disease research, and intervention studies.
- Future research will likely see further integration of metabolomics in understanding nutrition's role in health and disease.
