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Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice
Published on: September 25, 2019
Thymosin alpha-1 treatment in chronic hepatitis B
Xiaoning Wu1, Jidong Jia, Hong You
1Capital Medical University, Liver Research Center, Beijing Friendship Hospital, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis , 95 Yong-an Road, Xi-Cheng District, Beijing 100050 , China +86 10 6313 9019 ; +86 10 6302 3261 ; jia_jd@ccmu.edu.cn ; youhong30@sina.com.
Introduction:
Stimulating a successful host immune response may be a promising helpful therapy to achieve elimination of hepatitis B virus (HBV) infection in chronic hepatitis B (CHB). Thymosin α-1 (Tα-1), as an immunomodulatory agent, can enhance T-cell response in CHB patients and has been widely studied either alone or in combination with nucleos(t)ide analogs. This editorial reviews these articles to present the efficacy of Tα-1 in CHB.
Areas Covered:
English and Chinese articles in MEDLINE, EMBASE, the Cochrane Controlled Trial Registry, Chinese periodical full-text database of science and technology, Chinese periodical full-text database and Wan-fang database by thesis search were collected and reviewed.
Expert Opinion:
In CHB, Tα-1monotherapy is effective in suppressing viral replication compared with untreated control or conventional interferon. Most of the combination therapy of Tα-1 plus either lamivudine or IFN-α showed better effects on HBV DNA suppression and HBeAg seroconversion. Presently, clinical studies of Tα-1 combined with entecavir on the treatment of HBV-cirrhosis are ongoing.
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