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A Visual Assay to Monitor T6SS-mediated Bacterial Competition
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SecReT6: a web-based resource for type VI secretion systems found in bacteria.

Jun Li1, Yufeng Yao2, H Howard Xu3

  • 1State Key Laboratory for Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiaotong University, Shanghai, 200030, China.

Environmental Microbiology
|February 3, 2015
PubMed
Summary

SecReT6 is a new database for bacterial type VI secretion systems (T6SSs) and their effectors. It provides comprehensive data and analysis tools for researchers studying bacterial interactions.

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Area of Science:

  • Microbiology
  • Molecular Biology
  • Bioinformatics

Background:

  • Type VI secretion systems (T6SSs) are widespread in Gram-negative bacteria.
  • T6SSs mediate inter-bacterial and bacteria-eukaryote interactions.
  • Understanding T6SSs is crucial for studying bacterial pathogenesis and symbiosis.

Purpose of the Study:

  • To develop and present SecReT6, an integrated database for T6SSs.
  • To provide a comprehensive resource for exploring T6SS components, effectors, and immunity proteins.
  • To offer tools for T6SS gene cluster detection and comparative analysis.

Main Methods:

  • Data compilation from existing literature and computational predictions.
  • Database development with a focus on user accessibility and data integration.
  • Implementation of bioinformatics tools for T6SS analysis.

Main Results:

  • SecReT6 archives data on 11,167 core T6SS components across 906 T6SSs in 498 bacterial strains.
  • The database includes 1340 candidate effectors and 196 immunity proteins.
  • Integrated tools facilitate the identification of T6SS components, effectors, and immunity proteins.

Conclusions:

  • SecReT6 serves as a valuable, centralized resource for T6SS research.
  • The database and its tools will aid in the discovery and characterization of T6SSs.
  • Regular updates will ensure SecReT6 remains a relevant and useful tool for the scientific community.