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Cognition as a target in major depression: new developments.

Brisa Solé1, Esther Jiménez1, Anabel Martinez-Aran1

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European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
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PubMed
Summary
This summary is machine-generated.

Cognitive dysfunction in major depressive disorder (MDD) persists post-remission. This review examines emerging pharmacological treatments and complementary medicines targeting cognitive deficits in MDD patients.

Keywords:
Adjunctive treatmentCognitionMajor depressionMonotherapy

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Major depressive disorder (MDD) is a common and debilitating illness.
  • Cognitive dysfunction frequently accompanies MDD and can persist even after remission.
  • These persistent cognitive deficits negatively impact patients' functional outcomes.

Purpose of the Study:

  • To review pharmacological treatments targeting cognitive dysfunction in MDD.
  • To assess monotherapy and adjunctive treatment options.
  • To identify emerging therapies for cognitive enhancement in depression.

Main Methods:

  • Systematic literature search of PubMed/Medline until March 2014.
  • Inclusion of English-language articles.
  • Examination of bibliographies for additional relevant publications.

Main Results:

  • Several agents were reviewed, including modafinil, lisdexamfetamine, ketamine, memantine, galantamine, donepezil, vortioxetine, oxytocin, omega-3, SAMe, scopolamine, and erythropoietin.
  • Emerging data suggest promising new therapies, pharmacological agents, and complementary medicines.
  • Evidence is still developing for these interventions.

Conclusions:

  • Pharmacological and complementary therapies show potential for improving cognitive domains in MDD.
  • Further research is needed to validate efficacy and rule out pseudospecificity.
  • Targeting cognitive dysfunction is crucial for improving functional outcomes in MDD.