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Erythrocytic hydrogen sulfide production is increased in children with vasovagal syncope

Jinyan Yang1, Hongxia Li1, Todd Ochs2

  • 1Department of Pediatrics, Peking University First Hospital, Beijing, P. R. China.

The Journal of Pediatrics
|February 3, 2015
PubMed

Insights

Children with vasovagal syncope (VVS) show increased erythrocyte hydrogen sulfide (H2S) production. This finding suggests a potential role for H2S in the development of VVS in pediatric patients.

Area of Science:

  • Pediatric Cardiology
  • Biochemistry
  • Vascular Biology

Background:

  • Vasovagal syncope (VVS) is a common cause of syncope in children.
  • The underlying pathophysiology of VVS remains incompletely understood.
  • Hydrogen sulfide (H2S) is a gasotransmitter with known cardiovascular effects.

Purpose of the Study:

  • To investigate differences in erythrocyte hydrogen sulfide (H2S) production in children diagnosed with VVS.
  • To compare H2S production between VVS subtypes and healthy controls.
  • To explore the relationship between H2S production and endothelial function in VVS.

Main Methods:

  • A case-control study involving 54 children (27 with VVS, 27 controls) aged 6-17 years.
  • Erythrocyte H2S production was quantified using a sulphur-sensitive electrode.
  • Flow-mediated dilation (FMD) of the brachial artery was assessed via vascular ultrasound.

Main Results:

  • Erythrocyte H2S production was significantly elevated in children with VVS compared to controls (P < .01).
  • The VVS-vasoinhibitory subgroup exhibited higher H2S production and FMD compared to cardioinhibitory and mixed subgroups (P < .05).
  • A positive linear correlation was observed between erythrocytic H2S production and FMD in children with VVS (P < .05).

Conclusions:

  • Elevated erythrocyte H2S production is a notable finding in pediatric VVS.
  • Increased H2S may play a role in the pathogenesis of VVS in children.
  • Further research is warranted to elucidate the precise mechanisms linking H2S to VVS.
Abstract

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