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Improving drug biological effects by encapsulation into polymeric nanocapsules
Luiza A Frank1, Renata V Contri2, Ruy C R Beck1,2
1Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
|February 3, 2015
Summary
Polymeric nanocapsules enhance drug delivery by improving stability, modulating cell interactions, and increasing bioavailability. Studies show these nanoparticles offer improved therapeutic efficacy and safety across various drug classes.
Area of Science:
- Materials Science
- Nanotechnology
- Pharmaceutical Sciences
Background:
- Polymeric nanocapsules are advanced nanoparticles designed to improve drug delivery.
- Their unique structure offers advantages over traditional drug formulations.
- Recent research highlights their potential in enhancing therapeutic outcomes.
Purpose of the Study:
- To provide a comprehensive overview of polymeric nanocapsule applications in drug delivery.
- To detail the benefits, including improved drug stability, bioavailability, and reduced side effects.
- To review in vitro and in vivo studies demonstrating enhanced drug efficacy.
Main Methods:
- Literature review of selected reports from 2004 to 2014.
- Analysis of studies focusing on polymeric nanocapsules for drug delivery.
- Examination of in vitro and in vivo data for various therapeutic agents.
Main Results:
- Polymeric nanocapsules increase drug chemical and photostability.
- They modulate drug interactions with cells and tissues effectively.
- Encapsulation improves drug efficiency, bioavailability, and reduces adverse effects, particularly with lipid-core nanocapsules.
Conclusions:
- Polymeric nanocapsules represent a significant advancement in drug delivery systems.
- Their application leads to improved drug performance and potentially enhanced patient safety.
- Further research supports their role in developing next-generation therapeutics.