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[Antihistamines in pediatrics]
1Abteilung Kinderheilkunde 1, Medizinische Hochschule Hannover.
Insights
Histamine antagonists affect multiple receptors, with potentially different side effects in children, including central agitation. These drugs should be avoided in fetal and neonatal periods and are not recommended for the common cold.
Area of Science:
- Pharmacology
- Pediatrics
Context:
- Histamine antagonists interact with H1, H2, cholinergic, adrenergic, and serotoninergic receptors.
- Pediatric populations may exhibit distinct responses to histamine antagonists compared to adults.
Purpose:
- To discuss the use of histamine antagonists in childhood.
- To highlight potential differences in side effect profiles in pediatric patients.
- To emphasize contraindications for histamine antagonists.
Summary:
- Central agitation can be a more pronounced side effect in children treated with histamine antagonists.
- Histamine antagonists are contraindicated during fetal and neonatal development.
- These medications are not indicated for the treatment of the common cold.
Impact:
- Provides crucial information for pediatricians and healthcare providers regarding the safe and effective use of histamine antagonists.
- Informs clinical decision-making for managing conditions in children where histamine antagonists might be considered.
- Contributes to the understanding of age-specific pharmacodynamics and pharmacokinetics of histamine antagonists.
Abstract:
Histamine antagonists have various effects on H1, H2, cholinergic, adrenergic and serotoninergic receptors. In childhood side effects may be different and central agitation may be more pronounced than in adults. Histamine antagonists should be avoided in the fetal and neonatal periods. They are not indicated in common cold. The use of histamine antagonists in childhood will be discussed.