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Updated: Apr 18, 2026

Fabrication of Anisotropic Polymeric Artificial Antigen Presenting Cells for CD8+ T Cell Activation
Published on: October 12, 2018
Biodegradable nanoellipsoidal artificial antigen presenting cells for antigen specific T-cell activation
Randall A Meyer1, Joel C Sunshine, Karlo Perica
1Translational Tissue Engineering Center, Institute for Nanobiotechnology, Department of Biomedical Engineering, Johns Hopkins School of Medicine, 400 N Broadway, Baltimore, MD, 21231, USA.
Abstract:
Non-spherical nanodimensional artificial antigen presenting cells (naAPCs) offer the potential to systemically induce an effective antigen-specific immune response. In this report it is shown biodegradable ellipsoidal naAPCs mimic the T-Cell/APC interaction better than equivalent spherical naAPCs. In addition, it is demonstrated ellipsoidal naAPCs offer reduced non-specific cellular uptake and a superior pharmacokinetic profile compared to spherical naAPCs.
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