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Related Experiment Videos

Novel autonomic neurotransmitters and intestinal function.

G S Taylor1, R A Bywater

  • 1Department of Physiology, Monash University, Clayton, Victoria, Australia.

Pharmacology & Therapeutics
|January 1, 1989
PubMed
Summary

Researchers identified various amines and peptides in the enteric nervous system, exploring their effects on intestinal activity. Challenges in confirming neurotransmitter roles and the use of immunoblockade are discussed.

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Area of Science:

  • Neuroscience
  • Gastroenterology
  • Pharmacology

Background:

  • The enteric nervous system (ENS) utilizes diverse neurochemicals, including amines and peptides.
  • Immunohistochemical methods have revealed a wide array of these substances within the ENS.
  • Understanding the precise roles of these neurochemicals in intestinal function is crucial.

Purpose of the Study:

  • To review recent data on the effects of ENS neurochemicals on intestinal activity.
  • To discuss the challenges in definitively assigning neurotransmitter status to specific compounds.
  • To explore methods for identifying putative neurotransmitter substances in the ENS.

Main Methods:

  • Immunohistochemistry was employed to detect various amines and peptides in the ENS.

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  • The study discusses the application of immunoblockade to neurogenic functional responses.
  • Literature review of recent data on neurochemical effects on intestinal activity.

    • Main Results:

    • Numerous amines and peptides have been identified in the ENS.
    • Recent data on the impact of these substances on intestinal motility are presented.
    • The study highlights significant difficulties in confirming neurotransmitter roles.

    Conclusions:

    • Identifying neurotransmitters in the ENS remains a complex challenge.
    • Immunoblockade offers a potential strategy for identifying functional neurotransmitters.
    • The ongoing search for selective antagonists is critical for further research.