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Skeletal cryptococcosis from 1977 to 2013
Heng-Xing Zhou1, Lu Lu1, Tianci Chu1
1Department of Orthopaedics, Tianjin Medical University General Hospital Tianjin, China.
Frontiers in Microbiology
|February 3, 2015
Summary
Skeletal cryptococcosis is a rare fungal infection. While immune issues are a risk factor, they don't predict mortality, but dissemination of the disease requires combination therapy and has a worse prognosis.
Area of Science:
- Infectious Diseases
- Mycology
- Bone and Joint Infections
Background:
- Skeletal cryptococcosis is a rare manifestation of disseminated cryptococcal disease or isolated bone infection.
- Limited data exist on its clinical features, treatment, and prognosis.
Purpose of the Study:
- To systematically review published cases of skeletal cryptococcosis.
- To identify factors associated with the disease, including patient demographics, clinical presentation, diagnosis, treatment, and outcomes.
Main Methods:
- Systematic literature review of cases published between April 1977 and May 2013.
- Analysis of patient sex, age, epidemiological history, affected sites, symptoms, underlying diseases, laboratory tests, radiological findings, and diagnostic/treatment delays.
Main Results:
- Immune abnormality is a risk factor but does not predict mortality.
- Dissemination occurred irrespective of immune status and was associated with a worse prognosis.
- Combination therapy is required for disseminated disease.
Conclusions:
- Skeletal cryptococcosis is treatable but requires careful management, especially in disseminated cases.
- A centralized database for skeletal cryptococcosis cases is recommended for further research and improved understanding.
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