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Updated: Apr 18, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Alginate-peptide amphiphile core-shell microparticles as a targeted drug delivery system
Job Boekhoven1, R Helen Zha2, Faifan Tantakitti1
1Simpson Querrey Institute for BioNanotechnology, 303 E. Superior Ave, Chicago, IL 60611 ; Department of Chemistry, Department of Biomedical Engineering and Department of Chemical Engineering, Northwestern University, Tech Building, 2145 Sheridan Road, Evanston, IL 60208.
Abstract:
We describe in this work the synthesis of microparticles with a doxorubicin drug conjugated alginate core and a shell of peptide amphiphile nanofibres functionalized for targeting the folate receptor. The spherical geometry of the particle core allows high drug loading per surface area, whereas the nanoscale fibrous shell formed by self-assembly of peptide amphiphiles offers a high surface to volume ratio that is ideal for targeting. The synthesised microparticles have a 60-fold higher cytotoxicity against MDA-MB-231 breast cancer cells compared to non-targeting particles.
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