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Updated: Apr 18, 2026

Atomic Force Microscopy Imaging and Force Spectroscopy of Supported Lipid Bilayers
Published on: July 22, 2015
Bilayer properties of 1,3-diamidophospholipids
Andreas Weinberger1, Radu Tanasescu, Cristina Stefaniu
1Department of Chemistry, University of Fribourg , Chemin du Musée 9, 1700 Fribourg, Switzerland.
Abstract:
A series of 1,3-diamido phosphocholines was synthesized, and their potential to form stable bilayers was investigated. Large and giant unilamellar vesicles produced from these new lipids form a wide variety of faceted liposomes. Factors such as cooling rates and the careful choice of the liposome preparation method influence the formation of facets. Interdigitation was hypothesized as a main factor for the stabilization of facets and effectively monitored by small-angle X-ray scattering measurements.
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