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Haemodynamic effects of vecuronium
J M Wierda1, E Maestrone, A F Bencini
1Research Group of the Institutes for Experimental Anesthesiology and Clinical Pharmacology, The Netherlands.
British Journal of Anaesthesia
|February 1, 1989
Summary
This study found that vecuronium did not affect heart rate or blood pressure in patients undergoing general anesthesia. Diazepam and atropine premedication did not alter these findings.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Preoperative medication with diazepam and atropine is common.
- General anesthesia techniques include nitrous oxide-neurolept and nitrous oxide-halothane.
Purpose of the Study:
- To evaluate the effect of vecuronium on cardiovascular parameters during general anesthesia.
- To compare cardiovascular stability between nitrous oxide-neurolept and nitrous oxide-halothane anesthesia.
Main Methods:
- 320 adult patients (ASA grade I) received diazepam premedication.
- Patients were randomly assigned to nitrous oxide-neurolept or nitrous oxide-halothane anesthesia.
- Vecuronium was administered to 50% of patients in each group; heart rate and arterial pressure were monitored.
Main Results:
- Vecuronium administration did not significantly alter heart rate.
- Vecuronium did not influence systolic or diastolic arterial pressures.
- No significant differences in cardiovascular effects were noted between anesthetic techniques.
Conclusions:
- Vecuronium appears to be hemodynamically stable in patients undergoing general anesthesia with these techniques.
- Premedication with diazepam and atropine did not confound the cardiovascular effects of vecuronium.