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Updated: Apr 18, 2026

Using Optogenetics to Reverse Neuroplasticity and Inhibit Cocaine Seeking in Rats
Published on: October 5, 2021
Cocaine-evoked negative symptoms require AMPA receptor trafficking in the lateral habenula
Frank J Meye1, Kristina Valentinova1, Salvatore Lecca1
11] Institut du Fer à Moulin, Paris, France. [2] Inserm, UMR-S 839, Paris, France. [3] Université Pierre et Marie Curie, Paris, France.
Abstract:
Addictive substances mediate positive and negative states promoting persistent drug use. However, substrates for aversive effects of drugs remain elusive. We found that, in mouse lateral habenula (LHb) neurons targeting the rostromedial tegmental nucleus, cocaine enhanced glutamatergic transmission, reduced K(+) currents and increased excitability. GluA1 trafficking in LHb was instrumental for these cocaine-evoked modifications and drug-driven aversive behaviors. Altogether, our results suggest that long-lasting adaptations in LHb shape negative symptoms after drug taking.
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