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Proteomic biomarkers in kidney disease: issues in development and implementation
Harald Mischak1, Christian Delles1, Antonia Vlahou2
1Institute of Cardiovascular and Medical Sciences, University of Glasgow, 126 University Place, Glasgow G12 8TA, UK.
Nature Reviews. Nephrology
|February 4, 2015
Summary
Proteomic biomarkers show promise for earlier kidney disease detection and personalized treatment. This review covers current advancements, challenges, and future directions for clinical application in nephrology.
Area of Science:
- Nephrology
- Proteomics
- Biomarker Discovery
Background:
- Current kidney disease biomarkers (serum creatinine, urinary albumin) have limitations in accuracy and early detection.
- Proteomic biomarkers offer potential for improved diagnosis, prognosis, and therapeutic targeting in renal diseases.
Purpose of the Study:
- To review the current status of proteomic and protein biomarkers in kidney disease management.
- To highlight newly identified biomarkers with potential for clinical implementation in nephrology.
- To discuss challenges and solutions for proteomic biomarker discovery, validation, and application.
Main Methods:
- Review of existing literature on proteomic and protein biomarkers in kidney diseases.
- Analysis of lessons learned from early clinical studies.
- Overview of protein-based biomarker candidates undergoing development.
Main Results:
- Identification of promising proteomic biomarker candidates for kidney disease.
- Discussion of challenges in biomarker validation and clinical translation.
- Presentation of strategies to overcome obstacles in proteomic biomarker utilization.
Conclusions:
- Proteomic biomarkers hold significant potential to revolutionize kidney disease management.
- Addressing current challenges is crucial for successful clinical implementation.
- Future proteomic studies should be designed to facilitate biomarker translation.
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