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Maternal preeclampsia and childhood asthma in the offspring

Xiaoqin Liu1, Jørn Olsen, Esben Agerbo

  • 1Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark; Department of Epidemiology and Social Science on Reproductive Health, Shanghai Institute of Planned Parenthood Research, WHO Collaborating Center for Research in Human Reproduction, National Population & Family Planning Key Laboratory of Contraceptive Drugs and Devices, Shanghai, China.

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
|February 4, 2015
PubMed

Insights

Preeclampsia, a pregnancy complication, is linked to a higher risk of childhood asthma. Early-onset preeclampsia showed a stronger association, though shared family factors may play a role.

Area of Science:

  • Obstetrics and Gynecology
  • Pediatric Pulmonology
  • Epidemiology

Background:

  • Preeclampsia is a serious pregnancy complication.
  • A potential link exists between preeclampsia and childhood asthma.
  • Investigating shared familial factors is crucial for understanding this association.

Purpose of the Study:

  • To determine if preeclampsia is associated with childhood asthma.
  • To assess if shared sibling factors confound the preeclampsia-asthma link.

Main Methods:

  • A large cohort study of Danish singletons born 1993-2007 (N=923,533).
  • Nested case-control and case-sibling analyses were performed.
  • Conditional logistic regression estimated incidence rate ratios (IRR) for asthma.

Main Results:

  • Overall, maternal preeclampsia was associated with a 19% increased asthma risk (IRR=1.19).
  • Early-onset preeclampsia showed a higher IRR (1.88) compared to late-onset (1.14).
  • Case-sibling analysis indicated some confounding by shared factors, reducing the IRR for early-onset preeclampsia.

Conclusions:

  • Early-onset preeclampsia is associated with increased childhood asthma risk.
  • Shared familial factors partially explain the association.
  • Further research is needed to elucidate underlying mechanisms.
Abstract

Keywords:
asthmachildhoodpopulation basedpreeclampsia

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