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MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

MicroRNAs

MicroRNAs

RNA Interference

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...

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Related Experiment Video

Updated: Apr 17, 2026

Fecal micro RNA Isolation

Fecal micro RNA Isolation

Published on: October 28, 2020

Food derived microRNAs.

Anika E Wagner¹, Stefanie Piegholdt, Martin Ferraro

¹Institute of Human Nutrition and Food Science, Christian-Albrechts-University, Hermann-Rodewald-Str. 6, 24118 Kiel, Germany. wagner@molecularnutrition.uni-kiel.de.

Food & Function

|February 4, 2015

Summary

This summary is machine-generated.

Dietary microRNAs from food may impact human health by regulating gene expression. Further research is needed to understand the absorption and function of these food-derived microRNAs in mammals.

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Area of Science:

Nutrition
Molecular Biology
Genetics

Background:

Dietary factors like fats, carbohydrates, and proteins influence cellular processes.
MicroRNAs are key post-transcriptional regulators of gene expression.
MicroRNAs are present in both plant and animal-derived foods.

Purpose of the Study:

To investigate the potential influence of dietary microRNAs on endogenous microRNA expression.
To determine the extent of absorption of food-derived microRNAs in mammals.
To explore the role of dietary microRNAs in human health and disease.

Main Methods:

Analysis of microRNA content in various food sources.
In vivo studies to assess microRNA absorption and distribution.
Functional assays to evaluate the impact of dietary microRNAs on gene expression.

Main Results:

Confirmation of microRNA presence in plant and animal food sources.
Evidence suggesting potential, but not fully elucidated, absorption of dietary microRNAs in mammals.
Limited data currently available on the tissue distribution and functional significance of ingested microRNAs.

Conclusions:

Dietary microRNAs represent a potential, yet understudied, factor in nutrition and health.
Significant knowledge gaps exist regarding the bioavailability and functional consequences of consuming food-derived microRNAs.
Future research should prioritize elucidating the absorption, distribution, and functional roles of dietary microRNAs in mammals for a comprehensive understanding of their impact on human health and disease.