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Related Experiment Videos

Neuroleptic-resistant schizophrenics.

J B Murray1

  • 1Department of Psychology, St. John's University, Jamaica, NY 11439.

The Journal of Psychology
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

Neuroleptic drugs may effectively treat schizophrenia symptoms, challenging Crow's theory that negative symptoms are unresponsive. Further research is needed, but current evidence suggests broader treatment applicability for schizophrenia patients.

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Area of Science:

  • Psychiatry
  • Neuroscience
  • Pharmacology

Background:

  • Crow's positive-negative distinction posits differential neuroleptic response in schizophrenia.
  • This distinction suggests negative symptoms are less amenable to neuroleptic treatment.
  • Existing research presents mixed evidence regarding this hypothesis.

Purpose of the Study:

  • To evaluate the responsiveness of schizophrenia symptoms to neuroleptic drugs.
  • To critically assess the validity of Crow's positive-negative distinction in clinical practice.
  • To inform treatment guidelines for schizophrenia based on symptom response.

Main Methods:

  • Review of existing research literature on schizophrenia and neuroleptic treatment.
  • Analysis of studies comparing neuroleptic efficacy across positive and negative symptom domains.

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  • Synthesis of evidence to evaluate Crow's postulated distinction.

    • Main Results:

    • Evidence does not consistently support the expectation that negative symptoms of schizophrenia are less responsive to neuroleptic drugs.
    • Some aspects of Crow's hypothesized distinction show potential promise.
    • The overall efficacy of neuroleptics across symptom types requires further investigation.

    Conclusions:

    • Neuroleptic treatment should not be withheld from schizophrenic patients based solely on the presence of negative symptoms.
    • Crow's distinction may require refinement or re-evaluation in light of current evidence.
    • Additional research is necessary to fully elucidate the neurobiological underpinnings and treatment implications of schizophrenia symptom dimensions.